Breast cancer PDX

 

Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer


Marie-Emmanuelle Legrier1, Ivan Bièche2, Julie Gaston1, Arnaud Beurdeley1, Vanessa Yvonnet1, Olivier Déas1,
Aurélie Thuleau3, Sophie Château-Joubert4, Jean-Luc Servely4,5, Sophie Vacher2, Myriam Lassalle1,
Stéphane Depil6, Gordon C Tucker6, Jean-Jacques Fontaine4, Marie-France Poupon1, Sergio Roman-Roman3,
Jean-Gabriel Judde1, Didier Decaudin3,7, Stefano Cairo*,1,8,9 and Elisabetta Marangoni*,3,9

 

1 XenTech, 4 rue Pierre Fontaine, Evry 91000, France; 2 Genetics Department, Hospital, Institut Curie, 26 rue d’Ulm, Paris 75005, France; 3 Translational Research Department, Institut Curie, 26 rue d’Ulm, Paris 75005, France; 4 Department of Pathology, Veterinary School of Alfort, Maisons-Alfort 94704, France; 5 INRA, Phase Department, Nouzilly, France; 6Institut de Recherches Servier, PIT Oncology, Croissy-sur-Seine 78290, France; 7 Medical Oncology Department, Institut Curie, 26 rue d’Ulm, Paris 75005, France and 8 University of Ferrara, LTTA Centre, Department of Morphology, Surgery and Experimental Medicine, Ferrara, Italy

British Journal of Cancer (2015), 1–11 | doi: 10.1038/bjc.2015.398

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Cell-autonomous activation of the Interferon/STAT1 pathway in response to genotoxic treatment


Julie Gaston1,2 , Laura Cheradame1,2, Marie-Emmanuelle Legrier3, Olivier Déas1, Marie-France Poupon2, Jean-Gabriel Judde2, Vincent Goffin1 and Stefano Cairo2

1 Inserm 1151/Institute Necker Enfants Malades (INEM), Paris , France, 2 Xentech, Evry, France, 3 Institut Curie, Paris, France

Poster AACR-NCI-EORTC 2015

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The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features


Andrea Aloia1, Evgeniya Petrova2,3, Stefan Tomiuk1, Ute Bissels1, Olivier Déas2, Massimo Saini4,5, Franziska Maria Zickgraf4,5, Steve Wagner4,5, Saskia Spaich6, Marc Sütterlin6, Andreas Schneeweiss7, Manuel Reitberger4,5, Silvia Rüberg1, Bernhard Gerstmayer1, David Agorku1, Sebastian Knöbel1, Annalisa Terranegra8, Monica Falleni9, Laura Soldati9, Martin Ronald Sprick4,5, Andreas Trumpp4,5,10, Jean-Gabriel Judde2, Andreas Bosio1, Stefano Cairo2,11* and Olaf Hardt1*

Aloia et al. Breast Cancer Research (2015)

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Understanding breast cancer resistance to chemotherapy: Characterization of cancer cell sub-populations in residual and relapsed tumors


Andrea Aloia1, Evgeniya Petrova2, Olivier Deas3, Sophie Banis3, Enora Le Ven3, Andreas Bosio1, Olaf Hardt1, Stefano Cairo3, Jean-Gabriel Judde3.

1 Miltenyi Biotec GmbH, Bergisch Gladbach, Germany; 2 Institut Pasteur, Paris, France; 3 Xentech, Evry, France

Poster AACR 2014

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The sialyl-glycolipid SSEA4 marks a subpopulation of chemotherapy resistant breast cancer cells with mesenchymal features


Andrea Aloia1, Evgeniya Petrova2,3, Stefan Tomiuk1, Ute Bissels1, Sophie Banis2, Olivier Deas2, Silvia Rüberg1, Bernhard Gerstmayer1, David Agorku1, Jean-Gabriel Judde2, Andreas Bosio1, Olaf Hardt1 and Stefano Cairo2.

1 Miltenyi Biotec GmbH, Bergisch Gladbach, Germany; 2 Xentech, Evry, France; 3 Institut Pasteur, Paris, France.

Poster in collaboration with Miltenyi, AACR 2015

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XenTech patient-derived xenograft (PDX) panels: a clinically relevant platform for drug efficacy , target validation and predictive biomarker discovery studies


Pascal Leuraud, Stefano Cairo, Olivier Déas, Marie-France Poupon, Jean-Gabriel Judde. XenTech, Evry, France

Poster World Pharma Congress 2014

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Bioluminescent orthotopic PDX models of primary pancreatic cancer and residual/metastatic breast cancer to predict efficacy of standard of care and experimental treatments


Benjamin G. Cuiffo1, Ingrid Rankin1, Olivier Deas2, Gregory D. Lyng1, Stephano Cairo2, Enora Le Ven2, Jean-Gabriel Judde2, Stephen T. Sonis1.
1Biomodels, LLC, Watertown, MA, USA; 2XenTech, Evry, France

Poster in collaboration with Biomodels, 2014

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A platform of metastatic bioluminescent PDX: Focus on HBCx14-Luc1 metastatic bioluminescent breast tumorgraft model for preclinical studies


Ludovic Bourré , Mylène Bernes , Enora Leven , Vanessa Yvonnet , Olivier Déas , Myriam Lassalle and Jean-Gabriel Judde. Molecular Targets and Cancer Therapeutics Conference. 2013 Oct

 

Poster

 

Molecular profiling of patient-derived breast cancer xenografts


Reyal F, Guyader C, Decraene C, Lucchesi C, Auger N, Assayag F, De Plater L, Gentien D, Poupon MF, Cottu P, Decremoux P, Gestraud P, Vincent-Salomon A, Fontaine JJ, Roman-Roman S, Delattre O, Decaudin D, Marangoni E. Breast Cancer Res. 2012 Jan 16;14(1):R11.

 

Modeling of response to endocrine therapy in a panel of human luminal breast cancer xenografts


P. Cottu, E. Marangoni, F. Assayag, P. de Cremoux, A. Vincent-Salomon, Ch. Guyader, L. de Plater, C. Elbaz, N. Karboul, J. J. Fontaine, S. Chateau-Joubert, P. Boudou-Rouquette, S. Alran, V. Dangles-Marie, D. Gentien, M.-F. Poupon, D. Decaudin. Breast Cancer Res Treat. 2012 Jun;133(2):595-606.

 

 

 

Lung cancer PDX

 

Evidence linking EGFR signaling to gefitinib antitumor response


Judde JG, Rebucci M, Vogt N, de Cremoux P, Livartowski A, Chapelier A, Tran-Perennou C, Boye K, Defrance R, Poupon MF, Bras-Goncalves RA. Gefitinib and chemotherapy combination studies in five novel human non small cell lung cancer xenografts. Int J Cancer. 2007 Apr 1;120(7):1579-90.

 

In vivo efficacy of STI571 in xenografted human small cell lung cancer alone or combined with chemotherapy


Decaudin, D., de Cremoux, P., Sastre, X., Judde, J. G., Nemati, F., Tran-Perennou, C., Freneaux, P., Livartowski, A., Pouillart, P., and Poupon, M. F. (2005). In vivo efficacy of STI571 in xenografted human small cell lung cancer alone or combined with chemotherapy. Int J Cancer 113, 849-856.

 

 

 

Prostate cancer PDX

 

Potentiation of antitumour activity of docetaxel by combination with trastuzumab in a human prostate cancer xenograft model and underlying mechanisms


Legrier ME, Oudard S, Judde JG, Guyader C, de Pinieux G, Boye K, de Cremoux P, Dutrillaux B, Poupon MF. Br J Cancer. 2007 Jan 29;96(2):269-76.
Epub 2007 Jan 9.

 

Mucinous differentiation features associated with hormonal escape in a human prostate cancer xenograft


Legrier, M. E., de Pinieux, G., Boye, K., Arvelo, F., Judde, J. G., Fontaine, J. J., Bara, J., and Poupon, M. F. (2004). Mucinous differentiation features associated with hormonal escape in a human prostate cancer xenograft. Br J Cancer 90, 720-727.

 

Activity of Docetaxel With or Without Estramustine Phosphate Versus Mitoxantrone in Androgen Dependent and Independent Human Prostate Cancer Xenografts


Oudard, S., Legrier, M. E., Boye, K., Bras-Goncalves, R., De Pinieux, G., De Cremoux, P., and Poupon, M. F. (2003b). Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol 169, 1729-1734.

 

PAC120 xenograft is a new model of hormone-dependent prostate cancer, opening the oppotunity to study the hormone dependence escape mechanism and to evaluate the efficacity of new therapeutics


Legrier, M. E., de Pinieux, G., Poirson-Bichat, F., Apiou, F., Dutrillaux, A. M., Boye, K., Sihassen, A., Lidereau, R., Bara, J., Arvelo, F., Poupon, M.F. (2003). A new model of human prostate cancer, the PAC120 xenograft. Pathol Biol (Paris) 51, 1-4.

 

 

 

Colon cancer PDX

 

Establishment of human colon cancer cell lines from fresh tumors versus xenografts: comparison of success rate and cell line features


Dangles-Marie V, Pocard M, Richon S, Weiswald LB, Assayag F, Saulnier P, Judde JG, Janneau JL, Auger N, Validire P, Dutrillaux B, Praz F, Bellet D, Poupon MF. Cancer Res. 2007 Jan 1;67(1):398-407.

 

Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts


Carnesecchi, S., Bras-Goncalves, R., Bradaia, A., Zeisel, M., Gosse, F., Poupon, M. F., and Raul, F. (2004). Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett 215, 53-59.

 

Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis


Bras-Goncalves RA, Pocard M, Formento JL, Poirson-Bichat F, De Pinieux G, Pandrea I, Arvelo F, Ronco G, Villa P, Coquelle A, Milano G, Lesuffleur T, Dutrillaux B, Poupon MF: Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis. Gastroenterology 2001, 120:874-888.

 

 

 

Kidney cancer PDX

 

Human renal cell carcinoma xenografts in SCID mice: tumorigenicity correlates with a poor clinical prognosis.


Angevin E., Glukhova L., Pavon C., Chassevent A., Terrier-lacombe M.J., Goguel A.F., Bougaran J., Ardouin P., Court B.H., Perrin J.L., Vallancien G., Triebel F. and Escudier B. Lab. Invest. 1999;79(7):879–88.

 

 

 

Glioblastoma PDX

 

Distinct Responses of Xenografted Gliomas to Different Alkylating Agents Are Related to Histology and Genetic Alterations


Leuraud, P., Taillandier, L., Medioni, J., Aguirre-Cruz, L., Criniere, E., Marie, Y., Kujas, M., Golmard, J. L., Duprez, A., Delattre, J. Y., Poupon M.F. (2004). Distinct responses of xenografted gliomas to different alkylating agents are related to histology and genetic alterations. Cancer Res 64, 4648-4653.

 

Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas


Vogt, N., Lefevre, S. H., Apiou, F., Dutrillaux, A. M., Cor, A., Leuraud, P., Poupon, M. F., Dutrillaux, B., Debatisse, M., and Malfoy, B. (2004). Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas. Proc Natl Acad Sci U S A 101, 11368-11373.

 

Correlation between genetic alterations and growth of human malignant glioma xenografted in nude mice


Leuraud, P., Taillandier, L., Aguirre-Cruz, L., Medioni, J., Criniere, E., Marie, Y., Dutrillaux, A. M., Kujas, M., Duprez, A., Delattre, J. Y., Poupon, M.F.(2003). Correlation between genetic alterations and growth of human malignant glioma xenografted in nude mice. Br J Cancer 89, 2327-2332.

 

 

 

Pediatric liver cancer

 

Patient-derived xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management


Nicolle D1, Fabre M2, Simon-Coma M3,4, Gorse A1, Kappler R5, Nonell L6, Mallo M7, Haidar H8, Déas O1, Mussini C9, Guettier C9, Redon MJ9, Brugières L10, Rosa Ghigna M11, Fadel E12, Galmiche-Rolland L2, Chardot C13, Judde JG1, Armengol C3,4, Branchereau S14, Cairo S1,15

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A panel of pediatric liver cancer patient-derived xenografts to improve stratification of children with hepatoblastoma


Monique Fabre1, Delphine Nicolle2, Aurore Gorse2, Olivier Déas2, Charlotte Mussini3, Laurence Brugières4, Maria Rosa Ghigna5, Elie Fadel5, Louise Galmiche-Rolland1, Christophe Chardot1, Carolina Armengol, Jean-Gabriel Judde2, Sophie Branchereau3, and Stefano Cairo2.

1 Hôpital de Necker-Enfants Malades, Paris, France; 2 XenTech, Evry, France; 3 Hôpital de Bicêtre, Le Kremlin Bicêtre, France; France; 4 Institut Gustave Roussy, Villejuif, France; 5 Centre Chirurgical Marie Lannelongue, Le Plessis Robinson; Childhood Liver Cancer Research group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.

Poster ENA 2014

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Liver cancer patient-derived xenografts to improve disease management in childhood and adolescence: perspectives and challenges of personalized medicine


Stefano Cairo1, Aurore Gorse1, Delphine Nicolle1, Erwan Selingue1, Katell Mevel1, Frederic Gauthier2, Christophe Chardot3, Elie Fadel4, Dominique Elias5, Daniel Orbach6, Catherine Guettier2, Arnaud Beurdeley1,
Vanessa Yvonnet1, Olivier Deas1, Monique Fabre5, Laurence Brugières5, Sophie Branchereau2 and Jean-Gabriel Judde1.

1 XenTech, Evry, France; 2 Hôpital de Bicêtre, Le Kremlin Bicêtre, France; 3 Hôpital de
Necker-Enfants Malades, Paris, France; 4 Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France; 5 Institut Gustave Roussy, Villejuif, France; 6 Institut Curie, France.

 

Poster AACR, 2013

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A preclinical platform of mouse-transplanted human pediatric liver tumors to evaluate the efficacy of conventional and innovative anticancer therapy


Poster presented at the AACR meeting (April 2011).

 

 

 

2D PDX-derived primary cultures

 

A new and fast in vitro screen to predict in vivo drug efficacy using cell primary culture from patient derived tumor established xenografts


Poster presented at the EORTC-NCI-AACR symposium (Nov 2010).

 

 

 

Miscellaneous

 

A platform of metastatic bioluminescent PDX: Focus on HBCx14-Luc1 metastatic bioluminescent breast tumorgraft model for preclinical studies


Ludovic Bourré , Mylène Bernes , Enora Leven , Vanessa Yvonnet , Olivier Déas , Myriam Lassalle and Jean-Gabriel Judde. Molecular Targets and Cancer Therapeutics Conference. 2013 Oct

 

Poster

 

ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target


Bikeye et al.; Cancer Cell International 2010; 10:1.

 

STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells


Newman et al.; Clin Cancer Res 2008; 14(2): 597.

 

Myc Target miRs and Liver Cancer: Small Molecules to Get Myc Sick


MARIE–ANNICK BUENDIA, LUDOVIC BOURRE, and STEFANO CAIRO. GASTROENTEROLOGY 2012;142:214–218.

 

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function


Yatim A, Benne C, Sobhian B, Laurent-Chabalier S, Deas O, Judde JG, Lelievre JD, Levy Y, Benkirane M. Mol Cell. 2012 Nov 9;48(3):445-58.